immunohistochemical expression of pcna and ki-67 in periapical granuloma and radicular cyst
نویسندگان
چکیده
objective: periapical granulomas (pgs) and radicular cysts (rcs), as the most common odontogenic lesions have yet unclear pathogenesis. this study was aimed to compare pcna and ki-67 expression in pgs and rcs and evaluate their possible relationship with two lesions. methods: in this cross-sectional descriptive study, twenty pgs and twenty rcs were evaluated immunohistochemically using an anti-pcna and anti-ki-67 polyclonal antibodies. pcna+ and ki-67+ cells were counted in connective tissue wall and epithelial lining (in rcs). statistical analysis was performed by using mann-whitney u test and spearman’s rank correlation coefficient results: in pgs, percentage of pcna and ki-67 expression were found 70% and 30%, respectively; in rcs, pcna and ki-67 expression were observed 90% and 55%, respectively. additionally, in rcs, immunoexpression of pcna (85%) and ki-67 (60%) were detected at epithelial lining area. the positive immunoexpression of pcna in rcs was greater than pgs (p<0.05). conclusion immunoexpression of pcna and ki-67 were detected in both lesions which may be mentioned as valuable markers for the prediction of biologic behavior of pgs and rcs.
منابع مشابه
Immunohistochemical Expression of PCNA and Ki-67 in Periapical Granuloma and Radicular Cyst
Objectives: Periapical Granulomas (PGs) and Radicular Cysts (RCs), as the most common odontogenic lesions have yet unclear pathogenesis. This study was aimed to compare PCNA and Ki-67 expression in PGs and RCs and evaluate their possible relationship with two lesions. Methods: In this cross-sectional descriptive study, twenty PGs and twenty RCs were evaluated immunohistochemically using an a...
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عنوان ژورنال:
journal of dental school, shahid beheshti university of medical sciencesجلد ۳۴، شماره ۱، صفحات ۵۸-۶۵
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